9h15-10h00 – Registration & coffee

10h00-10h15 – Welcome and opening remarks

Local organizers – ISNOC
Pr. Vincent Thomas – President of Université Bourgogne Europe
Pr. François Ghiringhelli – Director of Center for Translational and Molecular Medicine (CTM)

10h15-10h30 – Lifetime achievement award
Pr. Benjamin Bonavida
Introduction of Awardee: Pr. Khosrow Kashfi

SESSION 1: NO in tumor: from dimensional distribution to therapeutic strategies and clinic
Chairs: Sharon Glynn and Katrina Miranda

10h30-11h15 – David A. Wink – National Cancer Institute, NIH, Frederick (MD, USA)

Keynote Lecture: Spatial geography of NOS2 and COX2 in the tumor microenvironment reveal aches that drive poor outcome

11h15-11h40 – Timothy R. Billiar – University of Pittsburgh (PA, USA)
NOS2-COX2 Inhibition Potentiates the Anti-tumor Potency of Checkpoint Inhibitors in Hepatocellular Cancer

11h40-12h05 – Jenny C. Chang – Houston Methodist Res. Institute (TX, USA)
Obesity, Metabolism, Cancer and Nitric oxide

General discussion

12h30-13h55 – Lunch Break

SESSION 2: NO in tumor: from dimensional distribution to therapeutic strategies and clinic
Chairs: Stéphanie Plenchette and Lucia Morbidelli

13h55-14h20 – Moran Benhar – Technion Israel Institute of Technology, Haifa (Israel)
Molecular mechanistic insights into reactive sulfur species mediated protection from inflammatory cell death

14h20-14h45 – Csaba Szabo – University of Fribourg (Switzerland)
Endogenously produced hydrogen sulfide supports the function of cancer cells

14h45 – 15h10 – Stéphanie Solier – Institut Curie, Paris (France)
Copper and plasticity

15h10-15h20 – Sharon Glynn – University of Galway (Ireland)
Presentation of the NO-CANCER-NET – Doctoral Network – Marie Sklodowska-Curie Actions (MSCA)

15h20-15h30 – Young investigator session: flash poster presentations
Letizia Incampo (Poster 1) – Danish Cancer Institute, Copenhagen (Denmark)
Mathew Choaji (Poster 2) –-Trinity College Dublin (Ireland)
Leonie Thomas (Poster 3) – University of Luxembourg (Luxembourg)
Elayne Neirynck (Poster 4) – CTM, EPHE-PSL, Dijon (France)

15h30-16h00 – Coffee Break

SESSION 3: Control of thiol-based redox signaling
Chairs: Moran Benhar and Salvatore Rizza

16h00-16h25 – Douglas D Thomas – University of Illinois Chicago (IL, USA)
“NO Trespassing” how nitric oxide hijacks non-heme iron proteins to control the epigenome

16h25-16h50 – Christopher Switzer – University of Leicester (UK)
Oxidative Signalling Mechanisms in Tumour Hypoxia

16h50-17h15 – Denis Stuehr – Lerner Research Institute, Cleveland (OH, USA)
Nitric oxide and hypoxia regulation of heme protein functions and potential role in cancer

17h15-17h25 Young investigator session: flash poster presentations
Xiling Song (Poster 5) – Institut des Matériaux Poreux de Paris (France)
Thenesia Govender (Poster 6) – National Research Council of Italy (Italy)
Erna Tintor (Poster 7) – University of Udine (Italy) Godspower Isaac (Poster 8) – University of Galway (Ireland)

17h25- 18h25 – POSTER SESSION

19h15-20h15 – Wine tasting at “ Ducal kitchens – Palace of the Dukes and States of Burgundy ”

20h30 – DINNER at the “ Central restaurant – Hotel IBIS Styles Dijon Central ”

SESSION 4 : NO in cancer and beyond: tumor microenvironment, immune response and metabolism
Chairs: Benjamin Bonavida and Giuseppe Filomeni

8h30-8h55 – Katrina Miranda  – University of Arizona, Tucson (AZ, USA) 
Impact of Exogenous and Endogenous Production of Nitroxyl in Cancer Cells 

8h55-9h20 – Emma Creagh  – Trinity College Dublin (Ireland) 
Inflammatory factors affecting TNBC tumour and infiltrating immune cell phenotype & function 

9h20-9h45 – Erika M. Palmieri – National Cancer Institute, NIH, Frederick (MD, USA)  
Metabolic reprogramming of Tumor Microenvironment by Nitric Oxide

9h45-10h10 – Csaba Szabo – University of Fribourg (Switzerland) 
Hydrogen cyanide, the fourth gasotransmitter exerts metabolic and tumor-cell-supporting roles in hepatoma cells 

10h10-10h40 – Coffee break

10h40-11h10 – Young investigator session: short talks
Chiara Pecorari – Danish Cancer Institute, Copenhagen (Denmark) 
Thomas Morin – CTM, EPHE-PSL, Dijon (France) 
Marta Ballester Martinez – Danish Cancer Institute Copenhagen (Denmark) 

SESSION 5: Angiogenesis, endothelial dysfunction and NO
Chairs: Lucia Morbidelli and Jordi Muntané 

11h10-11h35 – Jean-Philippe Gratton – University of Montréal (QC, Canada) 
Regulation of normal and pathological angiogenesis by endothelial nitric oxide synthase (eNOS).

11h35-12h00 – Valérie Schini-Kerth  – University of Strasbourg (France)
Sodium-glucose co-transporter 2: A novel therapeutic target in endothelial senescence and dysfunction promoting cardiovascular disease 

12h00-12h25 – Miriam M. Cortese-Krott – Heinrich Heine University Dusseldorf (Germany) 
The role of NO/sGC pathway in erythropoiesis

12h30-14h00 – Lunch Break

14h00-14h30 – Young investigator session: flash poster presentations
Elena Maresca (Poster 9) – Danish Cancer Institute, Copenhagen (Denmark) 
Tamara Weidemeier (Poster 10) – Institute of Biomedicine of Seville (IBiS) (Spain) 
Monika Migdalek (Poster 11) – University of Siena (Italy)
Maria Siegle (Poster 12) – University of Galway (Ireland) 

SESSION 6 – NO, cancer development and progression
Chairs: Stéphanie Plenchette and Emma Creagh 

14h10-14h35 – Maria Clara Franco – FIU Center for translational science (FL, USA) 
The Tumorigenic Role of Nitrated Proteins in Cancer 

14h35-15h00 – Jordi Muntané – Institute of Biomedicine of Seville (IBiS) (Spain) 
S-nitrosylation signature related to Sorafenib resistance in liver cancer cells 

15h00-15h25 – Giuseppe Filomeni – Danish Cancer Institute, Copenhagen (Denmark) 
Dual cysteines switches: How NO and H2O2 selectively tune TRAP1 oncogenicity 

15h25-15h55 – Young investigator session: short talks 
Ciara E. O’Neill – University of Galway (Ireland) 
Gianmarco Matrullo – University of Rome “Tor Vergata” (Italy) 
Rosana V. Pinto – University of Lisbon (Portugal) 

15h45-16h15 – Coffee break

SESSION 7 – Novel therapeutic considerations in NOS, NO delivery & drugs – Part 1
Chairs: Khosrow Kashfi and Giuseppe Filomeni 

16h15-16h40 – Benjamin Bonavida – University of California, Los Angeles (CA, USA) 
Does iNOS/NO facilitates immune evasion of cancer? 

16h40-17h05 – Thomas Sauter – University of Luxembourg (Luxembourg) 
Computational drug sensitivity prediction 

17h05-17h30 – Aryan Farahani – University of Medical Sciences, Tehran (Iran) 
Challenging the Paradigm: Constitutive Expression of iNOS and the Case for Revisiting NOS Nomenclature 

17h30-18h25 – POSTER SESSION

19h30 – Gala DINNER at “Restaurant La Closerie – Maison Philippe Le Bon ” 

SESSION 8 : Novel therapeutic considerations in NOS, NO delivery & drugs – Part 2
Chairs: Valentina Rapozzi and Thomas Sauter 

9h00-9h25 – Christian Serre – Institut des Matériaux Poreux de Paris (France) 
Biocompatible Metal-Organic Frameworks Gasotransmitters for Wound
Healing and Beyond

9h25-9h50 – Isabelle Malfant – Laboratoire de Chimie de Coordination (France)
Nitric oxide Photorelease – Coordination Chemistry and Therapeutic Perspectives

9h50-10h15 – Greta Varchi – National Research Council of Italy (Italy)
Targeting SMYD3-driven epigenetic pathways in cancer chemoresistance: advancing combination therapy strategies

10h15-10h45 – Coffee break

10h45-11h05 – In-Kyu Park – Chonnam National University (Rep. of Korea)
Stimuli-Responsive Nanocarriers Enable Controlled Nitric Oxide Delivery to Reprogram Tumor Immunity and Amplify Therapeutic Impact

Round-table discussion: “NO, Tumor Microenvironment Regulation, and Tumor-Specific Targeting:
Challenges and Future Directions”

Awards & concluding remarks 

12h00 –  END OF MEETING